.:: VIII SIMPÓSIO BRASILEIRO DE FARMACOGNOSIA ::.

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Program

PROGRAMA - (PROVISÓRIO) VIII SIMPÓSIO BRASILEIRO DE FARMACOGNOSIA I INTERNATIONAL SYMPOSIUM OF PHARMACOGNOSY
Wednesday, April 18th, 2012
	9:00h - 19:00h – Registry / secretary
	9:00h - Mini-course 1 – Sala Jorge Amado • Metabolomics applied to biotechnological products Thales Lima Rocha, Embrapa, Brasília; Fernanda Mulinari Fontana, Embrapa/UPIS, Brasília; Patrícia Barbosa Pelegrini, Embrapa, Brasília, Brazil Mini-course 2 – Sala Gabriela • Business Management and Entrepreneurship Thais Guaratini, Lychnoflora- P&D em produtos naturais, Ribeirão Preto, Brazil
12:00h – Lunch
	14:00h - Mini-curso Mini-course 3 – Sala Jorge Amado • Technological Innovation: Patents and Intellectual Property Fabiane Pereira Ramos Figueiredo, INPI, Rio de Janeiro, Brazil Mini-course 4 – Sala Gabriela • Access legislation on genetic resources and traditional knowledge Fernanda Alvares da Silva - Cenargen/Embrapa, Brasília, Brazil 17:00h - End of mini-courses 19:00h - Opening Ceremony – Sala Jorge Amado • Chair: Laila S. Espindola, UnB, Brasília; Cid Aimbiré Santos, UFPR, Curitiba • Invited guest of honor - Opening Lecture Bio-organic molecules: structural diversity and vital importance Prof. Dr. Raimundo Braz-Filho, FAPERJ/UENF/UFRRJ, Rio de Janeiro, Brazil Personalities and Association Presidents • University of Brasília (UnB) Márcia de Aguiar Ferreira, Decanato de Pesquisa e Pós-Graduação/UnB, Brazil • Sociedade Brasileira de Biotecnologia (SBBiotec) Maria Fatima Grossi de Sá, Embrapa/UCB, Brasília, Brazil • Sociedade Brasileira de Química (SBQ) Vanderlan da Silva Bolzani, UNESP, Araraquara, Brazil • Associação Brasileira de Ciências Farmacêuticas (ABCF) Suely L. Galdino, UFPE, PE, Brazil • Society for Medicinal Plant and Natural Product Research (GA) Matthias Hamburger, University of Basel, Switzerland • Association Francophone pour l'Enseignement et la Recherche en Pharmacognosie (AFERP) Sylvie Michel, University Paris-Descartes, France • American Society of Pharmacognosy (ASP) William Fenical, University of California San Diego, USA
	21:00h - Get-together Party
Thursday, April 19th, 2012
	8:30h - Marine Microbial Anticancer Agents Select for Novel Intracellular Targets - Sala Jorge Amado William Fenical, University of California, San Diego, USA Chairs: Laila Salmen Espindola-Darvenne, UnB, Brasília, Brazil and Letícia V. Costa-Lotufo, UFC, Fortaleza, Brazil 9:10h - Biodiversity and Chemistry: our life, our future - Sala Jorge Amado Vanderlan S. Bolzani, UNESP, Araraquara, Brazil Chairs: Laila S. Espindola, UnB, Brasília, Brazil and Letícia Veras C. Lotufo, UFC, Fortaleza, Brazil
09:50h - Coffee Break
	10:20h - • Synthesis, biosynthesis and biotransformations of natural products - Sala Jorge Amado Chair: Fernando Batista da Costa, USP, Ribeirão Preto, Brazil Rapporteur: Thales Lima Rocha, Embrapa, Brasília, Brazil • Recent progress towards the total synthesis of bioactive natural products Luiz Carlos Dias, UNICAMP, Campinas, Brazil • Biosynthesis: key in the dynamic aspects of the natural products chemistry Maysa Furlan, UNESP, Araraquara, Brazil • Biotransformations as tools for the functionalization of natural products Jacqueline A. Takahashi, UFMG, Belo Horizonte, Brazil Discussion • Plant metabolites - Sala Gabriela Chair: Raimundo Braz-Filho, FAPERJ/UENF/UFRRJ, Rio de Janeiro, Brazil Rapporteur: Renata Mendonça Araújo, UFRN, Natal, Brazil • Analysis of the secondary metabolism rhythm in “Arnicas da Serra” specimens Norberto Peporine Lopes, USP, Ribeirão Preto, Brazil • Plants of Caatinga, the northeastern Brazil flora: from the medicinal uses to chemical structure Edilberto Rocha Silveira, UFC, Fortaleza, CE, Brazil • Pharmacological activities of physalins isolated from Physalis angulata Milena B. P. Soares, FIOCRUZ, Salvador, Brazil Discussion • Technological innovation in companies – Sala Tororomba Chair: Maria Fatima Grossi de Sá, Embrapa/UCB, Brasília, Brazil Rapporteur: Fernanda Mulinari Fontana, Embrapa/UPIS, Brasília, Brazil • Innovation in Natural Products – The case of Lychnoflora Thais Guaratini, Lychnoflora- P&D em produtos naturais, Ribeirão Preto, Brazil • Genotyping biotechnology innovation through interaction of university/company Débora Colombi, Genotyping Biotecnologia - Prospecta, Botucatu, Brazil • Nanovetores - Innovating Naturelly Betina Giehl Zanetti Ramos, Nanovetores - Encapsulados de Alta Tecnologia, Florianópolis, Brazil Discussion
	12:00h - Lunch
	14:00h - • From biodiversity to chemodiversity – Sala Jorge Amado Chair: José Realino de Paula, UFG, Goiânia, Brazil Rapporteur: Cid Aimbiré M. Santos, UFPR, Curitiba, Brazil • Evolution of volatile compounds-based defenses against herbivory Didier Stien, ICSN/CNRS, France • Cryptocarya and Casearia. Models for the development of new drugs and to study ecophysiology of secondary metabolites Alberto José Cavalheiro, UNESP, Araraquara, Brazil • Latest technological advances in Pharmacognosy: evolution or revolution Jean-Luc Wolfender, University of Genève, Switzerland Discussion • Biopharmaceuticals – Sala Gabriela Chair: Maria Fatima Grossi de Sá, Embrapa/UCB, Brasília, Brazil Rapporteur: Paula Christine Jimenez, UFC, Fortaleza, Brazil • Dancing to the lights of a fluorescent natural product samba James La Clair, University of California, San Diego, USA • The efficacy of a nanostructured essential oil gel of Lippia sidoides in the treatment of Canker sore (Aphthae) Marco Antonio Botelho Soares, UnP, Natal, Brazil • Biopharmaceuticals production of high relevance for SUS Maria Fatima Grossi de Sá, Embrapa/UCB, Brasília, Brazil Discussion
	15:40h - Coffee Break
	16:10h - • Metabolomics, dereplication techniques and in silico design: key tools for profiling lead molecules on complex natural matrixes – Sala Jorge Amado Ian Castro-Gamboa, UNESP, Araraquara, Brazil Chairs: Cid Aimbiré M. Santos, UFPR, Curitiba, Brazil and João Pallazo de Mello, UEM, Maringá, Brazil 16:50h - • Naturally halogenated indirubin analogues: structural diversity and biological activity – Sala Jorge Amado Leandros Skaltsounis, University of Athens, Greece Chairs: Cid Aimbiré M. Santos, UFPR, Curitiba, Brazil and João Pallazo de Mello, UEM, Maringá, Brazil 17:30h - Poster Session (Odd-numbered posters) 19:30h - End of the activities
Friday, April 20th, 2012
	08:30h - • Seeing microbial interactions – Sala Jorge Amado Pieter Dorrestein, University of California San Diego, USA Chairs: Vanderlan S. Bolzani, UNESP, Araraquara, Brazil and José Carlos Tavares Carvalho, UNIFAP, Macapá, Brazil *09:10h* - • ICSN Pilot-Unit, an R&D key player in the discovery of bioactive natural compounds from microorganisms. AgSF, SSF & SSE combination – Sala Jorge Amado Jamal Ouazzani, ICSN/CNRS, France Chairs: Vanderlan S. Bolzani, UNESP, Araraquara, Brazil and José Carlos Tavares Carvalho, UNIFAP, Macapá, Brazil
	09:50h - Coffee Break
	10:20h - • Pharmacognosy and the use of in silico techniques for the study of natural compounds: a new trend toward the future - Sala Jorge Amado Chair: Norberto Peporine Lopes, USP, Ribeirão Preto, Brazil Rapporteur: João Pallazo de Mello, UEM, Maringá, Brazil • Identification of lead candidates from nature: in silico strategies combined with ethnopharmacological knowledge Hermann Stuppner, University of Innsbruck, Austria • Pharmacognosy and chemoinformatics: real, virtual or both? Fernando B. Costa, USP, Ribeirão Preto, Brazil • Medicinal chemistry approaches for structure- and ligand-based drug design Adriano Andricopulo, USP, São Carlos, Brazil Discussion • Resarch and graduation courses: impact on the international cooperation – Sala Gabriela Chair: Márcia de Aguiar Ferreira, Decanato de Pesquisa e Pós-Graduação/UnB Rapporteur: Thales Lima Rocha, Cenargen/Embrapa, Brasília, Brazil • Network Programs in research and graduation courses Maria Sueli Soares Felipe, UnB/UCB, Brasília, Brazil • ChemBioFight Maria Halabalaki, University of Athens, Greece • Biotechnology actions in Brasil: graduation courses and international interaction Maria Fatima Grossi de Sá, Embrapa/UCB - Coordenação Área Biotecnologia CAPES, Brasília, Brazil Discussion • Oral Presentations – Sala Tororomba Chair: José Carlos Tavares Carvalho, UNIFAP, Macapá, Brazil; Edilberto Rocha Silveira, UFC, Fortaleza, CE, Brazil Rapporteur: Wagner Luiz Ramos Barbosa, UFPA, Belém, Brazil OP1: Circular dichroism spectroscopy in drug discovery and development: the stereochemistry of drugs and biotechnological therapeutics Carlo Bertucci, Università di Bologna, Bologna, Italy *OP2: Photoautotrophic micropropagation of Pfaffia glomerata* (Spreng.) Pedersen enhances levels of 20-hydroxyecdisone** Leonardo Lucas Carnevalli Dias, Universidade Federal de Viçosa, Viçosa, Brazil *OP3: Stimulation of vascular endothelial growth factor in skin wounds in diabetic mice promoted by gel containing Stryphnodendron adstringens* extract** Eneri Vieira de Souza Leite-Mello, Universidade Estadual de Maringá, Maringá, Brazil *OP4: Pestalotin from endophytic fungus Pestalotiopsis guepinii* (pggvm-7)** Lourivaldo da Silva Santos, Universidade Federal do Pará, Belém, Brazil OP5: Detection and characterization of micromolecular constituents from Banisteriopsis variabilis - Malpighiaceae (B. GATES) using HPLC-DAD-HRMS combined with in silico techniques Marcos Marçal Ferreira Queiroz, UNESP, Araraquara, Brazil *OP6: A new xanthone and a series of tocotrienols isolated from Clusia pernambucensis* G. Mariz (Clusiaceae)** Everton Macêdo Silva, Universidade de Brasília, Brasília, Brazil OP7: Macrolide antibiotic produced by Streptomyces sp. RTd31, an endophyte of Tithonia diversifolia Larissa Varella, Universidade de São Paulo, Ribeirão Preto, Brazil *OP8: Biotransformation of piplartine by the endophytic fungus Penicillium crustosum* VR4** Eduardo Afonso Silva-Junior, Universidade de São Paulo, Ribeirão Preto, Brazil
	12:00h - Lunch
	14:00h - • Endophytic microorganisms as sources of bioactive natural products – Sala Jorge Amado Chair: Didier Stien, ICSN/CNRS, France Rapporteur: Mariana Laundry Mesquita, UnB, Brasília, Brazil • The amazing chemodiversity of endophytes: looking for natural and “unnatural” products Mônica Tallarico Pupo, USP, Ribeirão Preto, Brazil • Fungal Endophytes as Source of Bioactive Natural Products: the Costa Rican ICBG Giselle Tamayo, National Institute of Biodiversity, Costa Rica • Natural product chemistry of Panamanian endophytic fungi Luis Cubilla-Rios, Universidad de Panamá, Panama Discussion • Access to the genetic resources and technological innovation - Sala Gabriela Chair: Maria Sueli Soares Felipe, UnB/UCB, Brasília, Brazil Rapporteur: Jackson R. Guedes da Silva Almeida, UNIVASF, Petrolina, PE, Brazil • Legal Access to Biodiversity Fernanda Alvares da Silva - Cenargen, Embrapa, Brasília, Brazil • The importance of the intellectual property management at ECTIs and the interaction between ECTIs and Company in the innovation process Elza Fernandes de Araújo, UFV, Viçosa, Brazil • Patent granting in Brazil: genetic resources and associated tradicional knowledge protection and use Fabiane Pereira Ramos Figueiredo, INPI, Rio de Janeiro, Brazil • Scince and Legislation Rute Maria Gonçalves de Andrade, Instituto Butantan, São Paulo e UNIVASF, São Raimundo Nonato, PI Discussion
	15:40 - Coffee Break
	16:10h - • Poster Session (Even-numbered posters) • Members Meeting of the Brazilian Society of Pharmacognosy - Sala Jorge Amado 18:30h - 20:00h - WORKSHOP CHEMBIOFIGHT - Sala Jorge Amado • Exploring chemical biodiversity with innovative approaches for fighting Chagas’ disease and leishmaniasis FP7-PEOPLE-2010-IRSES Marie Curie Actions, International Research Staff Exchange Scheme (IRSES)
Saturday, April 21th, 2012
	08:30h - • Natural products and Chemistry. On some contributions of organic synthesis to natural products development: hopes and illusions - Sala Jorge Amado Georges Massiot - CNRS, France Chair: Maria Fatima Grossi de Sá, Embrapa/UCB, Brasília and Vanderlan S. Bolzani, UNESP, Araraquara, Brazil 09:10h - • Where ancient knowledge and modern science meets – examples from the the African flora - Sala Jorge Amado Alvaro Viljoen - Tshwane University of Technology, South Africa Chair: Maria Fatima Grossi de Sá, Embrapa/UCB, Brasília and Vanderlan S. Bolzani, UNESP, Araraquara, Brazil
	09:50h - Coffee Break
	10:20h - • Neglected diseases – Sala Jorge Amado Chair: Fernando Batista da Costa, USP, Ribeirão Preto, Brazil and Raphael Grougnet, Université Paris-Descartes, France Rapporteur: Lorena Carneiro Albernaz, UnB, Brasília, Brazil • Natural products with antiprotozoal activity - from HPLC-profiling to in vivo activity Matthias Hamburger, University of Basel, Switzerland • Semiochemically-baited sticky trap system to monitor Chagas’ disease vectors Antonieta R. Arias, Centro para el Desarrollo de la Investigacion Cientifica, Asuncion, Paraguay • Leishmaniasis and Nanotechnology Ricardo Bentes de Azevedo, UnB, Brasília, Brazil Discussion • Marine organisms: source of biologically active molecules - Sala Gabriela Chair: Valdir Florêncio da Veiga Júnior, UFAM, Manaus, Brazil Rapporteur: Renata Mendonça de Araújo, UFRN, Natal, Brazil • • Brazilian seas: source of new bioactive compounds Otilia Deusdênia Loiola Pessoa, UFC, Fortaleza, Brazil • Marine Biotechnology in Brazil: an ocean of possibilities Leticia V. Costa-Lotufo, UFC, Fortaleza, Brazil • Colombian Caribbean octocorals a good source of compounds for industrial purposes Carmenza D. Beltran, Colombia Discussion
	12:00h - Lunch
	14:00h – • Natural products: from bioactivity to drug conception - Sala Jorge Amado Chair: Ian Castro-Gamboa, UNESP, Araraquara, Brazil Rapporteur: Mariana Laundry de Mesquita, UnB, Brasília, Brazil • What is the best strategy for preclinical testing of botanicals? Veronika Butterweck, University of Applied Sciences Northwestern Switzerland, Switzerland • Immobilized enzyme reactors for inhibitors: screening and characterization Vincenza Andrisano - University of Bologna – Italy • Natural products models for the conception of bioactive compounds Sylvie Michel - Université Paris-Descartes - France Discussion • Oral Presentations – Sala Gabriela Chair: Norberto Peporine Lopes, USP, Ribeirão Preto, Brazil and João Pallazo de Mello, UEM, Maringá, Brazil Rapporteur: Wagner Luiz Ramos Barbosa, UFPA, Belém, Brazil OP09: CPC, principles and examples of application to the purification of polar and non-polar natural products Raphael Grougnet, Université Paris Descartes, Paris, France OP10: Glucagon biosimilar: new perspective for low-price biopharmaceutical products for SUS Angelina Maria Moreschi Basso, Universidade de Brasília, Brasília, Brazil OP11: Induction of flavonoid production in Pyrostegia venusta (Ker Gawl.) Miers. by callus cultures Mairon Cesar Coimbra, Universidade Federal de São João Del-Rei, Divinópolis, Brazil OP12: Rapid identification of furanoheliangolides by ESI-MS/MS in Eremanthus crotonoides (DC.) Sch. Bip. Jonathas Felipe Revoredo Lobo, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil *OP13: Activity of concentrated ethanolic extract from Physalis angulata* against Leishmania amazonensis in vitro and in vivo** Vinícius Pinto Costa Rocha, FIOCRUZ, Salvador, Brazil *OP14: Study of Neem oil and their nanocapsules on Lycopersicon esculentum* Mill. on attack of Bemisia tabaci biotype B** Israel Cívico Gil de Sá, Universidade Federal de São Carlos, São Carlos, Brazil *OP15: In vitro* photoprotection evaluation of Garcinia brasiliensis ethanolic extracts** Sônia Aparecida Figueiredo, Universidade de São Paulo, Ribeirão Preto, Brazil OP16: Identification of siderophores produced by the endophytic actinobacteria Streptomyces cattleya RLe 4 and Streptomyces sp RLe 8 Raphael Conti, Universidade de São Paulo, Ribeirão Preto, Brazil *OP17: Oxygenated sesquiterpenoid isolated from the essential oil of leaves from Eupatorium tremulum* HOOK. & ARN.** Tiago Juliano Tasso, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil OP18: Phytochemical investigation of the stem bark of Strychnos aff. darienensis Aikaterini Travasarou, University of Athens, Athens, Greece OP19: Metabolic profiling of Acronychia pedunculata, targeted isolation of acetophenone derivatives and evaluation of their cytotoxicity Eirini Kouloura, University of Athens, Athens, Greece

	16:10h - Closing Session – Sala Jorge Amado
Sunday, April 22th, 2012
	TOURISTIC PROGRAM 08 - 10:30h - WORKSHOP CHEMBIOFIGHT - Sala Gabriela • Exploring chemical biodiversity with innovative approaches for fighting Chagas’ disease and leishmaniasis FP7-PEOPLE-2010-IRSES Marie Curie Actions—International Research Staff Exchange Scheme (IRSES) 08:00h - Mini-course 5 - Part 1 - Sala Jorge Amado • Evidence-based practice: natural products Marcus Tolentino Silva, Ministério da Saúde, Brasília, Brazil Monitors: Phellipe Theodoro and Polyana Assis, UnB, Brasília, Brazil 09:00h - Mini-curse 6 - Sala Tororomba • Introduction to chemical ecology Raphael Grougnet - Université Paris-Descartes - França
	12:00h - Lunch
	13:00h - Mini-course 5 - Part 2 - Sala Jorge Amado • Evidence-based practice: natural products Marcus Tolentino Silva - Ministério da Saúde, Brasília, DF Monitors: Phellipe Theodoro and Polyana Assis, UnB, Brasília, Brazil 14:00h - Mini-course 7 • Preparation and submission of scientific papers Valdir Florêncio da Veiga Júnior – UFAM, Manaus, AM, Brazil 17h00 - End of the activities